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Antimicrobial Agents and Chemotherapy, February 2006, p. 799-802, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.799-802.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In117, an Unusual In0-Like Class 1 Integron Containing CR1 and blaCTX-M-2 and Associated with a Tn21-Like Element

Aránzazu Valverde,1 Rafael Cantón,1 Juan Carlos Galán,1 Patrice Nordmann,2 Fernando Baquero,1 and Teresa M. Coque1*

Hospital Universitario Ramón y Cajal, IMSALUD, Madrid, Spain,1 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université 9 Paris XI, K.-Bicêtre, France2

Received 15 June 2005/ Returned for modification 31 July 2005/ Accepted 7 November 2005

An unusual In0-like class 1 integron containing a common region that includes the putative recombinase gene named orf513 (CR1) and blaCTX-M-2 was characterized from Escherichia coli. The integron contained an unusual gene cassette array, estX-aadA1, embedded between the 5'-conserved segment (5'-CS) and 3'-CS1 regions and was flanked by mer-Tn21 sequences downstream of the tni truncated module. This element constitutes one of the few examples of CR1-bearing class 1 integrons that has been fully characterized.

* Corresponding author. Mailing address: Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Carretera de Colmenar, km. 9.1, Madrid 28034, Spain. Phone: 34-91-336 83 30. Fax: 34-91-336 88 09. E-mail: mcoque.hrc{at}salud.madrid.org.

Antimicrobial Agents and Chemotherapy, February 2006, p. 799-802, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.799-802.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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