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Antimicrobial Agents and Chemotherapy, February 2006, p. 813-816, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.813-816.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Pulsatile Delivery of Clarithromycin Alone or in Combination with Amoxicillin against Streptococcus pneumoniae

Kimberly D. Leuthner,1,3 Chrissy M. Cheung,1 and Michael J. Rybak1,2,3*

Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences,1 Department of Internal Medicine, Division of Infectious Diseases, School of Medicine, Wayne State University,2 Detroit Receiving Hospital and University Health Center, Detroit, Michigan3

Received 17 May 2005/ Returned for modification 30 July 2005/ Accepted 20 November 2005

We evaluated pulsatile dosing of clarithromycin and amoxicillin alone or combined against Streptococcus pneumoniae with various susceptibilities. When combined, pulsatile amoxicillin with clarithromycin was superior to either 8- or 12-h dosing against the intermediate strain and was identical for the susceptible strain. Pulse dosing of antimicrobials warrants further investigation.

* Corresponding author. Mailing address: Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, MI 48201. Phone: (313) 577-4376. Fax: (313) 577-8915. E-mail: m.rybak{at}wayne.edu.

Antimicrobial Agents and Chemotherapy, February 2006, p. 813-816, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.813-816.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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