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Antimicrobial Agents and Chemotherapy, April 2006, p. 1525-1527, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1525-1527.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vivo Selection of Fluoroquinolone-Resistant Escherichia coli Isolates Expressing Plasmid-Mediated Quinolone Resistance and Expanded-Spectrum ß-Lactamase

Laurent Poirel,1 Johann D. D. Pitout,2,3,4 Lucy Calvo,1 Jose-Manuel Rodriguez-Martinez,1,6 Deirdre Church,2,3,5 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275, K.-Bicêtre, France,1 Division of Microbiology, Calgary Laboratory Services,2 Departments of Pathology and Laboratory Medicine,3 Microbiology and Infectious Diseases,4 Medicine, University of Calgary, Alberta, Canada,5 University Hospital Virgen Macarena, University of Sevilla, Sevilla, Spain6

Received 20 September 2005/ Returned for modification 10 November 2005/ Accepted 2 February 2006

A ciprofloxacin-resistant Escherichia coli isolate, isolate 1B, was obtained from a urinary specimen of a Canadian patient treated with norfloxacin for infection due to a ciprofloxacin-susceptible isolate, isolate 1A. Both isolates harbored a plasmid-encoded sul1-type integron with qnrA1 and blaVEB-1 genes. Isolate 1B had amino acid substitutions in gyrase and topoisomerase.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, April 2006, p. 1525-1527, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1525-1527.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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