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Antimicrobial Agents and Chemotherapy, April 2006, p. 1531-1534, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1531-1534.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Plasmodium falciparum In Vitro Susceptibility to Antimalarial Drugs in Casamance (Southwestern Senegal) during the First 5 Years of Routine Use of Artesunate-Amodiaquine

P. Agnamey,1 P. Brasseur,2 P. Eldin de Pecoulas,3 Michel Vaillant,4 and P. Olliaro5,6*

Laboratoire de Parasitologie-Mycologie, Hôpital Hôtel Dieu, UFR Hôtel Dieu—Broussais, Université Paris V, Paris, France,1 UR 077, Institut de Recherche pour le Développement, Dakar, Sénégal,2 Faculté de Pharmacie, Université de Caen, Caen, France,3 Centre de Recherche Publique—Santé, Luxembourg,4 UNICEF/UNDP/WB/WHO Special Programme for Research & Training in Tropical Diseases, Geneva, Switzerland,5 Unité 3677, Bases thérapeutiques des inflammations et infections, Université Victor Segalen Bordeaux II, Bordeaux, France6

Received 19 August 2005/ Returned for modification 30 November 2005/ Accepted 13 January 2006

We have monitored the in vitro sensitivities of Plasmodium falciparum isolates predeployment and during the deployment of artesunate plus amodiaquine treatment in Mlomp, Casamance (southwestern Senegal) during 2000 to 2004. Parasites remained susceptible to both drugs. Chloroquine resistance levels were high but stable. Quinine continues to be effective.

* Corresponding author. Mailing address: WHO/TDR, Centre Casaï, 51-53 av. Louis Casaï, CH-1216 Cointrin, Genève, Switzerland. Phone: 41 22 7913734. Fax: 41 22 7914774. E-mail: olliarop{at}who.int.

Antimicrobial Agents and Chemotherapy, April 2006, p. 1531-1534, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1531-1534.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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