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Antimicrobial Agents and Chemotherapy, April 2006, p. 1567-1569, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1567-1569.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Sequential or Combination Antifungal Therapy with Voriconazole and Liposomal Amphotericin B in a Guinea Pig Model of Invasive Aspergillosis

William R. Kirkpatrick,1* Brent J. Coco,1 and Thomas F. Patterson1,2

Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900,1 Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 782842

Received 24 August 2005/ Returned for modification 23 November 2005/ Accepted 7 January 2006

We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.

* Corresponding author. Mailing address: The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229-3900. Phone: (210) 567-4823. Fax: (210) 567-3303. E-mail: kirkpatrick{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, April 2006, p. 1567-1569, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1567-1569.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Vallor, A. C., Kirkpatrick, W. R., Najvar, L. K., Bocanegra, R., Kinney, M. C., Fothergill, A. W., Herrera, M. L., Wickes, B. L., Graybill, J. R., Patterson, T. F. (2008). Assessment of Aspergillus fumigatus Burden in Pulmonary Tissue of Guinea Pigs by Quantitative PCR, Galactomannan Enzyme Immunoassay, and Quantitative Culture. Antimicrob. Agents Chemother. 52: 2593-2598 [Abstract] [Full Text]  


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