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Antimicrobial Agents and Chemotherapy, April 2006, p. 1603-1607, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1603-1607.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Large Conjugative Plasmids from Clinical Strains of Salmonella enterica Serovar Virchow Contain a Class 2 Integron in Addition to Class 1 Integrons and Several Non-Integron-Associated Drug Resistance Determinants

Irene Rodríguez,1 M. Rosario Rodicio,1 M. Carmen Mendoza,1* and M. Cruz Martín1,2

Departamento de Biología Funcional-Microbiología, Universidad de Oviedo and Instituto Universitario de Biotecnología de Asturias (IUBA), 33006-Oviedo, Spain,1 Instituto de Productos Lácteos de Asturias (CSIC), 33300-Villaviciosa, Asturias, Spain2

Received 26 September 2005/ Returned for modification 19 November 2005/ Accepted 8 February 2006

Two large conjugative resistance (R) plasmids from clinical strains of Salmonella enterica serovar Virchow carried a class 2 integron with the 5' conserved sequence (5'CS)-dfrA1-sat1-aadA1-3'CS gene array, which is associated with defective Tn7 transposons. In addition, each contained a different class 1 integron (with 5'CS-aadA1-3'CS or 5'CS-sat-smr-aadA1-3'CS gene arrays) linked to Tn21-Tn9 sequences, and several non-integron-associated R determinants. An intact copy of Tn7 (including the class 2 integron) was present in the chromosome of each strain.

* Corresponding author. Mailing address: Área de Microbiología, Facultad de Medicina, Universidad de Oviedo, Julián Clavería no. 6, 33006-Oviedo, Spain. Phone: 34 985103560. Fax: 34 985103148. E-mail: cmendoza{at}uniovi.es.

Antimicrobial Agents and Chemotherapy, April 2006, p. 1603-1607, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1603-1607.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Martinez, N., Mendoza, M. C., Rodriguez, I., Soto, S., Bances, M., Rodicio, M. R. (2007). Detailed structure of integrons and transposons carried by large conjugative plasmids responsible for multidrug resistance in diverse genomic types of Salmonella enterica serovar Brandenburg. J Antimicrob Chemother 60: 1227-1234 [Abstract] [Full Text]  
  • Machado, E., Ferreira, J., Novais, A., Peixe, L., Canton, R., Baquero, F., Coque, T. M. (2007). Preservation of Integron Types among Enterobacteriaceae Producing Extended-Spectrum {beta}-Lactamases in a Spanish Hospital over a 15-Year Period (1988 to 2003). Antimicrob. Agents Chemother. 51: 2201-2204 [Abstract] [Full Text]  
  • Rodriguez, I., Martin, M. C., Mendoza, M. C., Rodicio, M. R. (2006). Class 1 and class 2 integrons in non-prevalent serovars of Salmonella enterica: structure and association with transposons and plasmids. J Antimicrob Chemother 58: 1124-1132 [Abstract] [Full Text]  


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