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Antimicrobial Agents and Chemotherapy, May 2006, p. 1823-1827, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1823-1827.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

EDTA as an Adjunct Antifungal Agent for Invasive Pulmonary Aspergillosis in a Rodent Model

Ray Hachem,1* Paul Bahna,1 Hend Hanna,1 L. Clifton Stephens,2 and Issam Raad1

Departments of Infectious Diseases, Infection Control and Employee Health,1 Veterinary Medicine and Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas2

Received 9 August 2005/ Returned for modification 6 September 2005/ Accepted 6 February 2006

Rats immunosuppressed by the administration of cyclophosphamide and cortisone acetate and then infected with Aspergillus fumigatus were treated with an antifungal drug, EDTA, or a combination of one of the antifungal agents, amphotericin B lipid complex (ABLC; 5 mg/kg of body weight/day for 7 days), and EDTA (30 mg/kg/day for 7 days). The mortality rate was reduced, the duration of survival was increased, fewer A. fumigatus organisms were recovered from the lungs, and less-severe lung lesions were seen histopathologically in the rats receiving the combination treatment than in the rats receiving either an antifungal agent or EDTA alone. Further studies regarding the mechanisms of EDTA and its interactions with ABLC are warranted, and further studies are needed to more fully examine the safety, tolerance, and optimal dosing of EDTA in the treatment of this and other fungal infections.

* Corresponding author. Mailing address: Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, P.O. Box 301402, Houston, TX 77030-1402. Phone: (713) 792-4389. Fax: (713) 792-8233. E-mail: rhachem{at}mdanderson.org.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1823-1827, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1823-1827.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vallor, A. C., Kirkpatrick, W. R., Najvar, L. K., Bocanegra, R., Kinney, M. C., Fothergill, A. W., Herrera, M. L., Wickes, B. L., Graybill, J. R., Patterson, T. F. (2008). Assessment of Aspergillus fumigatus Burden in Pulmonary Tissue of Guinea Pigs by Quantitative PCR, Galactomannan Enzyme Immunoassay, and Quantitative Culture. Antimicrob. Agents Chemother. 52: 2593-2598 [Abstract] [Full Text]  


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