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Antimicrobial Agents and Chemotherapy, May 2006, p. 1852-1854, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1852-1854.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis

Elisabeth J. Ruijgrok,1* Marcel H. A. M. Fens,1 Irma A. J. M. Bakker-Woudenberg,1 Els W. M. van Etten,1 and Arnold G. Vulto2

Department of Medical Microbiology and Infectious Diseases,1 Hospital Pharmacy, Erasmus University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands2

Received 8 September 2004/ Returned for modification 18 October 2004/ Accepted 15 March 2005

Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.

* Corresponding author. Present address: Department of Clinical Pharmacy, Medical Center Rijnmond-Zuid, Olympiaweg 350, 3078 HT, Rotterdam, The Netherlands. Phone: 31 010 2912549. Fax: 31 010 2911037. E-mail: e.j.ruijgrok{at}hetnet.nl.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1852-1854, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1852-1854.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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