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Antimicrobial Agents and Chemotherapy, May 2006, p. 1865-1868, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1865-1868.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Efficacies of Various Catheter Lock Solutions

Robert J. Sherertz,1* Michael S. Boger,1 Casey A. Collins,1 Lori Mason,2 and Issam I. Raad3

Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina,1 Department of Infection Control, North Carolina Baptist Hospital, Winston-Salem, North Carolina,2 Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas3

Received 17 January 2006/ Accepted 17 February 2006

MEDTA (minocycline-edetate calcium disodium), taurolidine (2%)-polyvinylpyrolidine (5%) (T/PVP), and ethanol as potential catheter lock solutions have a unique mechanism of action, broad-spectrum activity, and anticoagulant properties. Traditional lock solutions minocycline (M), rifampin (R), ciprofloxacin (C), and vancomycin, except pharmacologic concentrations of C and R and of M and R, were less effective than MEDTA and T/PVP.

* Corresponding author. Mailing address: Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27517. Phone: (336) 716-4584. Fax: (336) 716-3825. E-mail: sherertz{at}wfubmc.edu.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1865-1868, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1865-1868.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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