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Antimicrobial Agents and Chemotherapy, May 2006, p. 1872-1874, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1872-1874.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Neuraminidase Inhibitor-Resistant and -Sensitive Influenza B Viruses Isolated from an Untreated Human Patient

Aeron C. Hurt,1,3* Pina Iannello,1 Kim Jachno,2 Naomi Komadina,1 Alan W. Hampson,1,3 Ian G. Barr,1,3 and Jennifer L. McKimm-Breschkin2

WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria 3052, Australia,1 CSIRO Molecular and Health Technologies, Parkville, Victoria 3052, Australia,2 School of Applied Sciences, Monash University, Churchill, Victoria 3842, Australia3

Received 30 August 2005/ Returned for modification 24 January 2006/ Accepted 13 February 2006

An influenza B virus from an infant with no history of treatment or contact with neuraminidase inhibitors demonstrated a significant reduction in sensitivity to these drugs. Here, we describe the analysis of a mixed viral population that contained a novel D197E amino acid substitution that was responsible for this reduction.

* Corresponding author. Mailing address: WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd., Parkville, Victoria 3052, Australia. Phone: 613 9389 1392. Fax: 613 9389 1881. E-mail: Aeron.Hurt{at}influenzacentre.org.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1872-1874, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1872-1874.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hurt, A. C., Holien, J. K., Barr, I. G. (2009). In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses. Antimicrob. Agents Chemother. 53: 4433-4440 [Abstract] [Full Text]  
  • Moscona, A., McKimm-Breschkin, J. (2007). News About Influenza B Drug Resistance That Cannot Be Ignored. JAMA 297: 1492-1493 [Full Text]  


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