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Antimicrobial Agents and Chemotherapy, May 2006, p. 1900-1902, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1900-1902.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Significance of Mutations in embB Codon 306 for Prediction of Ethambutol Resistance in Clinical Mycobacterium tuberculosis Isolates

Claudia Plinke, Sabine Rüsch-Gerdes, and Stefan Niemann*

Forschungszentrum Borstel, National Reference Center for Mycobacteria, D-23845 Borstel, Germany

Received 11 January 2006/ Returned for modification 20 January 2006/ Accepted 21 February 2006

We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB]-resistant strains, 33 multidrug-resistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 (embB306). Mutations were detected only in EMB-resistant strains (n = 69; 68%), thus confirming the significance of embB306 mutations for the prediction of resistance to EMB.

* Corresponding author. Mailing address: Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, D-23845 Borstel, Germany. Phone: (49) 4537-188762. Fax: (49) 4537-188311. E-mail: sniemann{at}fz-borstel.de.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1900-1902, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1900-1902.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hillemann, D., Rusch-Gerdes, S., Richter, E. (2009). Feasibility of the GenoType MTBDRsl Assay for Fluoroquinolone, Amikacin-Capreomycin, and Ethambutol Resistance Testing of Mycobacterium tuberculosis Strains and Clinical Specimens. J. Clin. Microbiol. 47: 1767-1772 [Abstract] [Full Text]  
  • Starks, A. M., Gumusboga, A., Plikaytis, B. B., Shinnick, T. M., Posey, J. E. (2009). Mutations at embB Codon 306 Are an Important Molecular Indicator of Ethambutol Resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 53: 1061-1066 [Abstract] [Full Text]  
  • Hazbon, M. H., Motiwala, A. S., Cavatore, M., Brimacombe, M., Whittam, T. S., Alland, D. (2008). Convergent Evolutionary Analysis Identifies Significant Mutations in Drug Resistance Targets of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 52: 3369-3376 [Abstract] [Full Text]  
  • Safi, H., Sayers, B., Hazbon, M. H., Alland, D. (2008). Transfer of embB Codon 306 Mutations into Clinical Mycobacterium tuberculosis Strains Alters Susceptibility to Ethambutol, Isoniazid, and Rifampin. Antimicrob. Agents Chemother. 52: 2027-2034 [Abstract] [Full Text]  
  • Shen, X., Shen, G.-m., Wu, J., Gui, X.-h., Li, X., Mei, J., DeRiemer, K., Gao, Q. (2007). Association between embB Codon 306 Mutations and Drug Resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 51: 2618-2620 [Abstract] [Full Text]  


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