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Antimicrobial Agents and Chemotherapy, June 2006, p. 2261-2264, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01407-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro and In Vivo Antibacterial Activities of DW-224a, a New Fluoronaphthyridone

Hee-Soo Park,1 Hyun-Joo Kim,1 Min-Jung Seol,1 Dong-Rack Choi,2 Eung-Chil Choi,3 and Jin-Hwan Kwak1*

School of Life and Food Sciences, Handong Global University, Kyungbuk, Republic of Korea,1 Dong Wha Pharmaceutical Industry Ltd., Anyang City, Republic of Korea,2 College of Pharmacy, Seoul National University, Seoul, Republic of Korea3

Received 31 October 2005/ Returned for modification 27 December 2005/ Accepted 21 March 2006

DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

* Corresponding author. Mailing address: School of Life and Food Sciences, Handong Global University, Puk-ku, Pohang City, Kyungbuk 791-708, Republic of Korea. Phone: 82-54-260-1353. Fax: 82-54-260-1925. E-mail: jhkwak{at}handong.edu.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2261-2264, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01407-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Park, H. S., Yoon, Y. M., Jung, S. J., Kim, C. M., Kim, J. M., Kwak, J.-H. (2007). Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor. J Antimicrob Chemother 60: 568-574 [Abstract] [Full Text]  


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