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Antimicrobial Agents and Chemotherapy, June 2006, p. 2265-2267, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00190-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Microdialysis Study of Imipenem Distribution in Skeletal Muscle and Lung Extracellular Fluids of Acinetobacter baumannii-Infected Rats

Claire Dahyot,1,2 Sandrine Marchand,1,3 Greisiele Lorena Pessini,1 Claudine Pariat,1 Bertrand Debaene,2 William Couet,1,3* and Olivier Mimoz1,2

EA 3809, Faculté de Médecine et de Pharmacie de Poitiers, Poitiers, France,1 Département d'Anesthésie et Réanimation Chirurgicale, CHU de Poitiers, Poitiers, France,2 Laboratoire de Toxicologie-Pharmacocinétique, CHU de Poitiers, Poitiers, France3

Received 13 February 2006/ Returned for modification 24 March 2006/ Accepted 7 April 2006

The aim of this study was to investigate imipenem distribution in muscle and lung interstitial fluids of rats with Acinetobacter baumannii pulmonary infection. By combining microdialysis in blood and tissues, it was possible to demonstrate that free imipenem concentrations were virtually identical in blood, muscle, and lung.

* Corresponding author. Mailing address: EA 3809, Pôle Biologie Santé (PBS), Médecine-Sud, Niveau 1, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France. Phone: 33-5-49-45-43-79. Fax: 33-5-49-45-43-78. E-mail: william.couet{at}univ-poitiers.fr.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2265-2267, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00190-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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