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Antimicrobial Agents and Chemotherapy, August 2006, p. 2814-2819, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00220-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Peptide Immunization as an Adjuvant to Chemotherapy in Mice Challenged Intratracheally with Virulent Yeast Cells of Paracoccidioides brasiliensis

A. F. Marques,1 M. B. da Silva,1 M. A. P. Juliano,2 L. R. Travassos,3 and C. P. Taborda1*

Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, SP, Brazil; and Departments of,1 Biophysics,2 Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, SP, Brazil3

Received 20 February 2006/ Returned for modification 1 April 2006/ Accepted 13 May 2006

Immunization with peptide P10, derived from gp43, and chemotherapy were used together in an attempt to improve treatment of paracoccidioidomycosis and prevent relapses. The combined treatment showed an additive protective effect when administered at 48 h or 30 days after intratracheal challenge. Its use is recommended to improve regular chemotherapy and reduce the duration of treatment.

* Corresponding author. Mailing address: Instituto de Ciências Biomédicas II, Departamento de Microbiologia, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1374, 2° andar, São Paulo, SP 05508-900, Brazil. Phone: 55-11-3091-7345. Fax: 55-11-3091-7354. E-mail: taborda{at}usp.br.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2814-2819, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00220-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • de Bastos Ascenco Soares, R., Gomez, F. J., de Almeida Soares, C. M., Deepe, G. S. Jr. (2008). Vaccination with Heat Shock Protein 60 Induces a Protective Immune Response against Experimental Paracoccidioides brasiliensis Pulmonary Infection. Infect. Immun. 76: 4214-4221 [Abstract] [Full Text]  
  • Carvalho, K. C., Vallejo, M. C., Camargo, Z. P., Puccia, R. (2008). Use of Recombinant gp43 Isoforms Expressed in Pichia pastoris for Diagnosis of Paracoccidioidomycosis. CVI 15: 622-629 [Abstract] [Full Text]  
  • Iwai, L. K., Yoshida, M., Sadahiro, A., da Silva, W. R., Marin, M. L., Goldberg, A. C., Juliano, M. A., Juliano, L., Shikanai-Yasuda, M. A., Kalil, J., Cunha-Neto, E., Travassos, L. R. (2007). T-Cell Recognition of Paracoccidioides brasiliensis gp43-Derived Peptides in Patients with Paracoccidioidomycosis and Healthy Individuals. CVI 14: 474-476 [Abstract] [Full Text]  


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