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Antimicrobial Agents and Chemotherapy, August 2006, p. 2869-2871, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00270-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

AG205, a Novel Agent Directed against FabK of Streptococcus pneumoniae

Sho Takahata,* Maiko Iida, Yumi Osaki, Jun Saito, Hideo Kitagawa, Tomohiro Ozawa, Takuji Yoshida, and Shigeru Hoshiko

Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan

Received 3 March 2006/ Returned for modification 20 March 2006/ Accepted 4 May 2006

AG205 was identified from high-throughput screening as a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae. Specific inhibition of lipid biosynthesis in a macromolecular biosynthesis assay and identification of an Ala141Ser substitution in FabK from spontaneous AG205-resistant mutants indicated that AG205 exerts antibacterial activity against S. pneumoniae through the specific inhibition of FabK.

* Corresponding author. Mailing address: Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. Phone: 81-45-545-3139. Fax: 81-45-541-1768. E-mail: sho_takahata{at}meiji.co.jp.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2869-2871, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00270-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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