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Antimicrobial Agents and Chemotherapy, August 2006, p. 2892-2894, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00349-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Candida albicans and Candida glabrata Clinical Isolates Exhibiting Reduced Echinocandin Susceptibility

Santosh Katiyar,1 Michael Pfaller,2 and Thomas Edlind1*

Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129,1 Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 522422

Received 22 March 2006/ Returned for modification 10 May 2006/ Accepted 2 June 2006

A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C. albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C. glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129. Phone: (215) 991-8377. Fax: (215) 848-2271. E-mail: tedlind{at}drexelmed.edu.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2892-2894, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00349-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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