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Antimicrobial Agents and Chemotherapy, September 2006, p. 3150-3153, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00141-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Efflux Pump Overexpression in Multiple-Antibiotic-Resistant Mutants of Bacteroides fragilis

Lilian Pumbwe,1,2 Daniel Glass,2 and Hannah M. Wexler1,2*

Greater Los Angeles Veterans Administration Healthcare Systems,1 Department of Medicine, University of California, Los Angeles, Los Angeles, California2

Received 2 February 2006/ Returned for modification 13 April 2006/ Accepted 12 June 1006

Multidrug-resistant mutants of a wild-type Bacteroides fragilis strain (strain ADB77) and a quadruple resistance nodulation division family efflux pump deletion mutant (ADB77 {Delta}bmeB1 {Delta}bmeB3 {Delta}bmeB12 {Delta}bmeB15) were selected with antimicrobials. Ampicillin, doripenem, imipenem, levofloxacin, and metronidazole selected for mutants from both strains; cefoxitin selected for mutants from strain ADB77 only; and sodium dodecyl sulfate selected mutants from ADB77{Delta}bmeB1 {Delta}bmeB3 {Delta}bmeB12 {Delta}bmeB15 only. The mutants overexpressed one or more efflux pumps.

* Corresponding author. Mailing address: Wadsworth Anaerobe Laboratory, School of Medicine, University of California, Los Angeles, Bldg. 304, Room E3-224, GLAVAHCS 691/151J, Los Angeles, CA 90073. Phone: (310) 268-3404. Fax: (310) 268-4458. E-mail: hwexler{at}ucla.edu.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3150-3153, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00141-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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