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Antimicrobial Agents and Chemotherapy, January 2007, p. 354-358, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00344-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of the Lipopeptides Palmitoyl (Pal)-Lys-Lys-NH2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-Positive Cocci{triangledown}

Wojciech Kamysz,1 Carmela Silvestri,2 Oscar Cirioni,2 Andrea Giacometti,2* Alberto Licci,2 Agnese Della Vittoria,2 Marcin Okroj,3 and Giorgio Scalise2

Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland,1 Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy,2 Lund University, Department of Laboratory Medicine, Malmö University Hospital, Malmö, Sweden3

Received 22 March 2006/ Returned for modification 30 August 2006/ Accepted 10 October 2006

The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH2 and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.

* Corresponding author. Mailing address: Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona I 60020, Italy. Phone: 39-071-5963715. Fax: 39-071-5963468. E-mail: a.giacometti{at}univpm.it.

{triangledown} Published ahead of print on 23 October 2006.

Antimicrobial Agents and Chemotherapy, January 2007, p. 354-358, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00344-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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