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Antimicrobial Agents and Chemotherapy, January 2007, p. 369-371, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00824-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae: Contribution of the FCY2, FCY1, and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance{triangledown}

Nicolas Papon,1 Thierry Noël,2 Martine Florent,1 Stéphanie Gibot-Leclerc,1 Dorothée Jean,1 Christiane Chastin,1 Jean Villard,1 and Florence Chapeland-Leclerc1*

Laboratoire des Sciences Végétales, EA209, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris 5, 4 avenue de l'Observatoire, 75006 Paris, France,1 Laboratoire de Mycologie Moléculaire, UMR 5162 CNRS-Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France2

Received 7 July 2006/ Returned for modification 4 August 2006/ Accepted 16 October 2006

Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.

* Corresponding author. Mailing address: Laboratoire des Sciences Végétales, EA209, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris 5, 4 avenue de l'Observatoire, 75006 Paris, France. Phone: (33) 1 53 73 96 41. Fax: (33) 1 53 73 96 40. E-mail: florence.leclerc{at}univ-paris5.fr.

{triangledown} Published ahead of print on 23 October 2006.

Antimicrobial Agents and Chemotherapy, January 2007, p. 369-371, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00824-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • McManus, B. A., Moran, G. P., Higgins, J. A., Sullivan, D. J., Coleman, D. C. (2009). A Ser29Leu Substitution in the Cytosine Deaminase Fca1p Is Responsible for Clade-Specific Flucytosine Resistance in Candida dubliniensis. Antimicrob. Agents Chemother. 53: 4678-4685 [Abstract] [Full Text]  
  • Florent, M., Noel, T., Ruprich-Robert, G., Da Silva, B., Fitton-Ouhabi, V., Chastin, C., Papon, N., Chapeland-Leclerc, F. (2009). Nonsense and Missense Mutations in FCY2 and FCY1 Genes Are Responsible for Flucytosine Resistance and Flucytosine-Fluconazole Cross-Resistance in Clinical Isolates of Candida lusitaniae. Antimicrob. Agents Chemother. 53: 2982-2990 [Abstract] [Full Text]  
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  • Chapeland-Leclerc, F., Paccallet, P., Ruprich-Robert, G., Reboutier, D., Chastin, C., Papon, N. (2007). Differential Involvement of Histidine Kinase Receptors in Pseudohyphal Development, Stress Adaptation, and Drug Sensitivity of the Opportunistic Yeast Candida lusitaniae. Eukaryot Cell 6: 1782-1794 [Abstract] [Full Text]  


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