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Antimicrobial Agents and Chemotherapy, January 2007, p. 372-375, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00355-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Effect of Carbapenem Administration on Establishment of Intestinal Colonization by Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice{triangledown}

Usha Stiefel,1,2 Nicole J. Pultz,1 and Curtis J. Donskey1,2*

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio,1 Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio2

Received 23 March 2006/ Returned for modification 12 June 2006/ Accepted 10 October 2006

In a mouse model, ertapenem inhibited the anaerobic intestinal microflora and promoted overgrowth of enterococci, whereas imipenem-cilastatin had no effect on the indigenous microflora. Ertapenem, but not imipenem-cilastatin, promoted modest overgrowth of vancomycin-resistant enterococci when exposure occurred during treatment. Neither agent promoted colonization with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae.

* Corresponding author. Mailing address: Infectious Diseases Section (111 W), Louis Stokes Cleveland Department of VA Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, ext. 5103. E-mail: curtisd123{at}yahoo.com.

{triangledown} Published ahead of print on 16 October 2006.

Antimicrobial Agents and Chemotherapy, January 2007, p. 372-375, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00355-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pultz, M. J., Donskey, C. J. (2007). Effects of Imipenem-Cilastatin, Ertapenem, Piperacillin-Tazobactam, and Ceftriaxone Treatments on Persistence of Intestinal Colonization by Extended-Spectrum-{beta}-Lactamase-Producing Klebsiella pneumoniae Strains in Mice. Antimicrob. Agents Chemother. 51: 3044-3045 [Full Text]  


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