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Antimicrobial Agents and Chemotherapy, October 2007, p. 3737-3739, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00730-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Orally Administered Combined Regimens for Treatment of Mycobacterium ulcerans Infection in Mice{triangledown}

Baohong Ji,* Aurélie Chauffour, Jérôme Robert, Sébastien Lefrançois, and Vincent Jarlier

Bactériologie-Hygiène, Faculté de Médecine Pierre et Marie Curie, Université Paris 6, Paris, France

Received 6 June 2007/ Returned for modification 9 July 2007/ Accepted 20 July 2007

Eight weeks of treatment with rifampin-streptomycin sterilizes Mycobacterium ulcerans infection in mice. Because the bactericidal activity against M. ulcerans of the combination rifampin-moxifloxacin, rifampin-clarithromycin, or moxifloxacin-clarithromycin was similar to that of rifampin-streptomycin, these combinations might be considered as alternative, orally administered combined regimens for treatment of Buruli ulcer in humans.

* Corresponding author. Mailing address: Bacteriologie-Hygiène, Faculté de Médecine Pierre et Marie Curie, Université Paris 6, 91 boulevard de l'Hôpital, 75634 Paris Cedex 13, France. Phone: (331) 40 77 98 67. Fax: (331) 45 82 75 77. E-mail: baohong_ji{at}yahoo.com

{triangledown} Published ahead of print on 30 July 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3737-3739, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00730-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ji, B., Chauffour, A., Aubry, A., Robert, J., Ibrahim, M., Jarlier, V. (2009). Impacts of Dosing Frequency of the Combination Rifampin-Streptomycin on Its Bactericidal and Sterilizing Activities against Mycobacterium ulcerans in Mice. Antimicrob. Agents Chemother. 53: 2955-2959 [Abstract] [Full Text]  
  • Ji, B., Chauffour, A., Robert, J., Jarlier, V. (2008). Bactericidal and Sterilizing Activities of Several Orally Administered Combined Regimens against Mycobacterium ulcerans in Mice. Antimicrob. Agents Chemother. 52: 1912-1916 [Abstract] [Full Text]  


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