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Antimicrobial Agents and Chemotherapy, October 2007, p. 3740-3742, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00925-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Enhancement of Apoptosis of THP-1 Cells Infected with Mycobacterium tuberculosis by Inhalable Microparticles and Relevance to Bactericidal Activity{triangledown}

Awadh Bihari Yadav and Amit Misra*

Pharmaceutics Division, Central Drug Research Institute, Lucknow 226001, India

Received 17 July 2007/ Accepted 20 July 2007

The relevance of apoptosis to killing of intracellular Mycobacterium tuberculosis was studied with phorbol-differentiated THP-1 cells. Microparticles containing isoniazid and rifabutin induced intrinsic apoptosis and bacterial killing equivalent to that with dissolved drugs and maximally enhanced purinergic P2 receptor activity, while drug-free microparticles induced apoptosis via a different mechanism without killing bacteria.

* Corresponding author. Mailing address: Pharmaceutics Division, Central Drug Research Institute, Chhattar Manzil Palace, Lucknow 226001, India. Phone: 91-522-261-2411, ext. 4302. Fax: 91-522-261-4305. E-mail: amit.cdri{at}gmail.com

{triangledown} Published ahead of print on 30 July 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3740-3742, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00925-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Verma, R. K., Kaur, J., Kumar, K., Yadav, A. B., Misra, A. (2008). Intracellular Time Course, Pharmacokinetics, and Biodistribution of Isoniazid and Rifabutin following Pulmonary Delivery of Inhalable Microparticles to Mice. Antimicrob. Agents Chemother. 52: 3195-3201 [Abstract] [Full Text]  


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