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Antimicrobial Agents and Chemotherapy, October 2007, p. 3763-3767, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00389-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Plasmid-Encoded ACC-4, an Extended-Spectrum Cephalosporinase Variant from Escherichia coli{triangledown}

Costas C. Papagiannitsis,1 Leonidas S. Tzouvelekis,2 Eva Tzelepi,1 and Vivi Miriagou1*

Laboratory of Bacteriology, Hellenic Pasteur Institute,1 Department of Microbiology, School of Medicine, University of Athens, Athens, Greece2

Received 22 March 2007/ Returned for modification 25 May 2007/ Accepted 21 July 2007

ACC-4, an omega loop mutant (Val211->Gly) of the Hafnia alvei-derived cephalosporinase ACC-1, was encoded by an Escherichia coli plasmid. The genetic environment of blaACC-4 shared similarities with plasmidic regions carrying blaACC-1. Kinetics of ß-lactam hydrolysis and levels of resistance to ß-lactams showed that ACC-4 was more effective than ACC-1 against expanded-spectrum cephalosporins.

* Corresponding author. Mailing address: Laboratory of Bacteriology, Hellenic Pasteur Institute, Vas. Sofias 127, Athens 11521, Greece. Phone: 30-210-6478810. Fax: 30-210-6425038. E-mail: miriagou{at}mail.pasteur.gr

{triangledown} Published ahead of print on 30 July 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3763-3767, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00389-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kotsakis, S. D., Papagiannitsis, C. C., Tzelepi, E., Tzouvelekis, L. S., Miriagou, V. (2009). Extended-Spectrum Properties of CMY-30, a Val211Gly Mutant of CMY-2 Cephalosporinase. Antimicrob. Agents Chemother. 53: 3520-3523 [Abstract] [Full Text]  
  • Zioga, A., Whichard, J. M., Kotsakis, S. D., Tzouvelekis, L. S., Tzelepi, E., Miriagou, V. (2009). CMY-31 and CMY-36 Cephalosporinases Encoded by ColE1-Like Plasmids. Antimicrob. Agents Chemother. 53: 1256-1259 [Abstract] [Full Text]  
  • Jacoby, G. A. (2009). AmpC {beta}-Lactamases. Clin. Microbiol. Rev. 22: 161-182 [Abstract] [Full Text]  


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