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Antimicrobial Agents and Chemotherapy, October 2007, p. 3768-3770, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00239-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Trioxaquines and Heme-Artemisinin Adducts Inhibit the In Vitro Formation of Hemozoin Better than Chloroquine{triangledown}

Christophe Loup,1* Joël Lelièvre,1,2 Françoise Benoit-Vical,1,2* and Bernard Meunier3

Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, 31077 Toulouse cedex 4, France,1 CHU Rangueil, Service de Parasitologie et Mycologie, 1 avenue Jean Poulhès, TSA 50032, 31059 Toulouse cedex 9, France,2 Palumed, rue Pierre et Marie Curie, BP 28262, 31682 Labège cedex, France3

Received 16 February 2007/ Returned for modification 16 April 2007/ Accepted 1 August 2007

Trioxaquines, potential antimalarial agents, and heme-artemisinin adducts, resulting from the alkylation of heme by artemisinin, were evaluated as inhibitors of ß-hematin formation in 10 M acetate medium at pH 5.

* Corresponding author. Mailing address for Christophe Loup: Laboratoire de Chimie de Coordination, CNRS, 205 Route de Narbonne, 31000 Toulouse cedex 4, France. Phone: 33 5 61 33 31 48. Fax: 33 5 61 32 20 96. E-mail: christophe.loup{at}lcc-toulouse.fr. Mailing address for Françoise Benoit-Vical: CHU Rangueil, Service de Parasitologie et Mycologie, 1 Av. Jean Poulhès, TSA 50032, 31059 Toulouse cedex 9, France. Phone: 33 5 61 32 34 46. Fax: 33 5 61 32 20 96. E-mail: francoise.vical{at}toulouse.inserm.fr

{triangledown} Published ahead of print on 13 August 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3768-3770, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00239-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cosledan, F., Fraisse, L., Pellet, A., Guillou, F., Mordmuller, B., Kremsner, P. G., Moreno, A., Mazier, D., Maffrand, J.-P., Meunier, B. (2008). Selection of a trioxaquine as an antimalarial drug candidate. Proc. Natl. Acad. Sci. USA 105: 17579-17584 [Abstract] [Full Text]  
  • Bousejra-El Garah, F., Claparols, C., Benoit-Vical, F., Meunier, B., Robert, A. (2008). The Antimalarial Trioxaquine DU1301 Alkylates Heme in Malaria-Infected Mice. Antimicrob. Agents Chemother. 52: 2966-2969 [Abstract] [Full Text]  


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