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Antimicrobial Agents and Chemotherapy, November 2007, p. 4157-4159, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00619-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antibiotic Resistance and Single-Nucleotide Polymorphism Cluster Grouping Type in a Multinational Sample of Resistant Mycobacterium tuberculosis Isolates{triangledown}

M. Brimacombe,1* M. Hazbon,2 A. S. Motiwala,2 and D. Alland2

Department of Preventive Medicine and Community Health,1 Department of Medicine, New Jersey Medical School—UMDNJ, Newark, New Jersey 070832

Received 10 May 2007/ Returned for modification 22 August 2007/ Accepted 25 August 2007

A single-nucleotide polymorphism-based cluster grouping (SCG) classification system for Mycobacterium tuberculosis was used to examine antibiotic resistance type and resistance mutations in relationship to specific evolutionary lineages. Drug resistance and resistance mutations were seen across all SCGs. SCG-2 had higher proportions of katG codon 315 mutations and resistance to four drugs.

* Corresponding author. Mailing address: Department of Preventive Medicine and Community Health, New Jersey Medical School—UMDNJ, 185 S. Orange Ave., MSB F-647, Newark, NJ 07083. Phone: (973) 972-5229. Fax: (973) 972-7625. E-mail: brimacmb{at}umdnj.edu

{triangledown} Published ahead of print on 10 September 2007.

Antimicrobial Agents and Chemotherapy, November 2007, p. 4157-4159, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00619-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hazbon, M. H., Motiwala, A. S., Cavatore, M., Brimacombe, M., Whittam, T. S., Alland, D. (2008). Convergent Evolutionary Analysis Identifies Significant Mutations in Drug Resistance Targets of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 52: 3369-3376 [Abstract] [Full Text]  


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