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Antimicrobial Agents and Chemotherapy, November 2007, p. 4167-4170, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00166-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Galanin Message-Associated Peptide Suppresses Growth and the Budded-to-Hyphal-Form Transition of Candida albicans{triangledown}

Isabella Rauch,1 Linda Lundström,2 Markus Hell,3 Wolfgang Sperl,1 and Barbara Kofler1*

Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria,1 Department of Neurochemistry, Stockholm University, Stockholm, Sweden,2 Department of Hospital Epidemiology and Infection Control, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria3

Received 5 February 2007/ Returned for modification 13 April 2007/ Accepted 5 August 2007

The expression of the mRNA encoding galanin message-associated peptide (GMAP) in human keratinocytes is upregulated by lipopolysaccharides and exposure to Candida albicans. GMAP has growth-inhibiting activity against C. albicans and inhibits the budded-to-hyphal-form transition, establishing GMAP as a possible new component of the innate immune system.

* Corresponding author. Mailing address: Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstr. 48, A-5020 Salzburg, Austria. Phone: 4366244824741. Fax: 4366244824765. E-mail: b.kofler{at}salk.at

{triangledown} Published ahead of print on 13 August 2007.

Antimicrobial Agents and Chemotherapy, November 2007, p. 4167-4170, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00166-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rauch, I., Holzmeister, S., Kofler, B. (2009). Anti-Candida activity of {alpha}-melanocyte-stimulating hormone ({alpha}-MSH) peptides. J. Leukoc. Biol. 85: 371-372 [Abstract] [Full Text]  


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