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 Previous Article

Antimicrobial Agents and Chemotherapy, November 2007, p. 4214-4216, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.01589-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Effects of Serum on In Vitro Susceptibility Testing of Echinocandins{triangledown}

Zekaver Odabasi,1* Victor Paetznick,2 John H. Rex,2,{dagger} and Luis Ostrosky-Zeichner2

Marmara University Hospital, Istanbul, Turkey University of Texas Health Science Center, Houston, Texas

Received 20 December 2006/ Returned for modification 3 April 2007/ Accepted 26 August 2007

The effects of protein binding on the activities of caspofungin, anidulafungin, and micafungin were evaluated against Candida and Aspergillus species. Adding human serum sharply increased the MICs of micafungin and anidulafungin and modestly affected the MIC of caspofungin. The increase in MICs does not appear consistent with the rate of protein binding for the three compounds.

* Corresponding author. Mailing address: Marmara University Hospital, Tophanelioglu caddesi, No:13, 34662 Altunizade, Istanbul, Turkey. Phone and fax: 90 212 327 4142. E-mail: zekaver{at}marmara.edu.tr

{triangledown} Published ahead of print on 4 September 2007.

{dagger} Present address: AstraZeneca Pharmaceuticals, Alderley House, Alderley Park, Macclesfield, United Kingdom SK10 4TF.

Antimicrobial Agents and Chemotherapy, November 2007, p. 4214-4216, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.01589-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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