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Antimicrobial Agents and Chemotherapy, December 2007, p. 4466-4470, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00726-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Complex Class 1 Integrons with Diverse Variable Regions, Including aac(6')-Ib-cr, and a Novel Allele, qnrB10, Associated with ISCR1 in Clinical Enterobacterial Isolates from Argentina{triangledown}

María Paula Quiroga,1,{dagger} Patricia Andres,2,{dagger} Alejandro Petroni,2 Alfonso J. C. Soler Bistué,3 Leonor Guerriero,2 Liliana Jordá Vargas,1 Angeles Zorreguieta,3 Marta Tokumoto,4 Cecilia Quiroga,1 Marcelo E. Tolmasky,5 Marcelo Galas,2 and Daniela Centrón1*

Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires,1 Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas—ANLIS Carlos G. Malbrán, Buenos Aires,2 Fundación Instituto Leloir, CONICET, FCEyN, Universidad de Buenos Aires, Buenos Aires,3 Instituto de Cardiología y Cirugía Cardiovascular (ICYCC) Fundación Favaloro, Buenos Aires, Argentina,4 California State University Fullerton, Fullerton, California5

Received 5 June 2007/ Returned for modification 12 July 2007/ Accepted 2 October 2007

Transferable quinolone resistance has not previously been reported in Argentina. Here we describe three complex class 1 integrons harboring the novel allele qnrB10 in a unique region downstream of orf513, one of them also containing aac(6')-Ib-cr within the variable region of integrons. The three arrays differed from blaCTX-M-2-bearing integrons, which are broadly distributed in Argentina.

* Corresponding author. Mailing address: Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, P-12, Ciudad Autónoma de Buenos Aires, Argentina. Phone: 54 11 5950-9500, ext. 2171. Fax: 54 11 4964 2554. E-mail: dcentron{at}gmail.com

{triangledown} Published ahead of print on 15 October 2007.

{dagger} María P. Quiroga and Patricia Andres contributed equally to this work.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4466-4470, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00726-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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