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Antimicrobial Agents and Chemotherapy, February 2007, p. 766-769, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.00615-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Caenorhabditis elegans as a Model To Determine Fitness of Antibiotic-Resistant Salmonella enterica Serovar Typhimurium ^,

Wilhelm Paulander,^1, Alexandra Pennhag,^1, Dan I. Andersson,^1,2 and Sophie Maisnier-Patin^1*

Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology and Tumor Center, Karolinska Institute, S-171 82 Solna, Sweden,¹ Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S-751 23 Uppsala, Sweden²

Received 19 May 2006/ Returned for modification 6 August 2006/ Accepted 23 August 2006

We used the ability of Salmonella enterica serovar Typhimurium to colonize the gut of Caenorhabditis elegans to measure the fitness costs imposed by antibiotic resistance mutations. The fitness costs determined in the nematode were similar to those measured in mice, validating its use as a simple host model to evaluate bacterial fitness.

Published ahead of print on 20 November 2006.

Supplemental material for this article may be found at http://aac.asm.org/.

W.P. and A.P. contributed equally to this study.