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Antimicrobial Agents and Chemotherapy, February 2007, p. 794-795, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.01145-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Aspirin Antagonism in Isoniazid Treatment of Tuberculosis in Mice{triangledown}

Sean T. Byrne, Steven M. Denkin, and Ying Zhang*

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

Received 12 September 2006/ Returned for modification 27 October 2006/ Accepted 22 November 2006

Salicylate has previously been shown to reduce the susceptibility of Mycobacterium tuberculosis to several drugs in vitro. In this study, aspirin, a salicylate anti-inflammatory, antagonized isoniazid treatment of murine pulmonary tuberculosis, whereas the nonsalicylate ibuprofen did not. These results may have implications on concurrent administration of anti-inflammatory and antituberculosis drugs.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205. Phone: (410) 614-2975. Fax: (410) 955-0105. E-mail: yzhang{at}jhsph.edu.

{triangledown} Published ahead of print on 4 December 2006.

Antimicrobial Agents and Chemotherapy, February 2007, p. 794-795, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.01145-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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