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Antimicrobial Agents and Chemotherapy, March 2007, p. 1082-1084, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.00909-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Detection of a New SHV-Type Extended-Spectrum ß-Lactamase, SHV-31, in a Klebsiella pneumoniae Strain Causing a Large Nosocomial Outbreak in The Netherlands{triangledown}

A. Mazzariol,1 E. Roelofsen,2 R. Koncan,1 A. Voss,3 and G. Cornaglia1*

Department of Pathology, University of Verona, Verona, Italy,1 Regional Laboratory of Public Health, Enschede, Overijssel, The Netherlands,2 Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital and Radboud University Medical Center, Nijmegen, Gelderland, The Netherlands3

Received 24 July 2006/ Returned for modification 2 September 2006/ Accepted 6 December 2006

A Klebsiella pneumoniae strain resistant to third-generation cephalosporins was isolated in the eastern Netherlands. The strain was found to carry a novel extended-spectrum ß-lactamase, namely, SHV-31. The combination of the two mutations by which SHV-31 differs from SHV-1, namely, L35Q and E240K, had previously only been described in association with one or more additional mutations.

* Corresponding author. Mailing address: Department of Pathology, University of Verona, Verona, Italy. Phone: 39-045-8027196. Fax: 39-045-584606. E-mail: giuseppe.cornaglia{at}univr.it.

{triangledown} Published ahead of print on 18 December 2006.

Antimicrobial Agents and Chemotherapy, March 2007, p. 1082-1084, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.00909-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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