This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhou, J.
Right arrow Articles by Saiman, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhou, J.
Right arrow Articles by Saiman, L.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, March 2007, p. 1085-1088, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.00954-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibility and Synergy Studies of Burkholderia cepacia Complex Isolated from Patients with Cystic Fibrosis{triangledown}

Juyan Zhou, Yunhua Chen, Setareh Tabibi, Luis Alba, Elizabeth Garber, and Lisa Saiman*

Department of Pediatrics, Columbia University, New York, New York 10032

Received 2 August 2006/ Returned for modification 7 September 2006/ Accepted 30 November 2006

Susceptibility (18 antimicrobial agents including high-dose tobramycin) and checkerboard synergy (23 combinations) studies were performed for 2,621 strains of Burkholderia cepacia complex isolated from 1,257 cystic fibrosis patients. Minocycline, meropenem, and ceftazidime were the most active, inhibiting 38%, 26%, and 23% of strains, respectively. Synergy was rarely noted (range, 1% to 15% of strains per antibiotic combination).

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Pediatrics, Columbia University, College of Physicians & Surgeons, 650 West 168th Street, PH 4 West Room 470, New York, NY 10032. Phone: (212) 305-9446. Fax: (212) 305-9491. E-mail: LS5{at}columbia.edu.

{triangledown} Published ahead of print on 11 December 2006.

Antimicrobial Agents and Chemotherapy, March 2007, p. 1085-1088, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.00954-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Peeters, E., Nelis, H. J., Coenye, T. (2009). In vitro activity of ceftazidime, ciprofloxacin, meropenem, minocycline, tobramycin and trimethoprim/sulfamethoxazole against planktonic and sessile Burkholderia cepacia complex bacteria. J Antimicrob Chemother 64: 801-809 [Abstract] [Full Text]  
  • Poirel, L., Rodriguez-Martinez, J.-M., Plesiat, P., Nordmann, P. (2009). Naturally Occurring Class A ss-Lactamases from the Burkholderia cepacia Complex. Antimicrob. Agents Chemother. 53: 876-882 [Abstract] [Full Text]  
  • Flannagan, R. S., Valvano, M. A. (2008). Burkholderia cenocepacia requires RpoE for growth under stress conditions and delay of phagolysosomal fusion in macrophages. Microbiology 154: 643-653 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»