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Antimicrobial Agents and Chemotherapy, March 2007, p. 1109-1111, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.01256-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii{triangledown}

Aaron T. Smith,1 Meredith R. Livingston,1 Antonello Mai,2 Patrizia Filetici,3 Sherry F. Queener,1 and William J. Sullivan Jr.1*

Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, Indiana,1 Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universita degli Studi di Roma "La Sapienza," P.le A. Moro 5, I-00185 Rome, Italy,2 Istituto di Biologia e Patologia Molecolari CNR, Dipartimento Genetica e Biologia Molecolare, Universita degli Studi di Roma "La Sapienza," P.le A. Moro 5, I-00185 Rome, Italy3

Received 6 October 2006/ Returned for modification 19 November 2006/ Accepted 6 December 2006

We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.

* Corresponding author. Mailing address: Department of Pharmacology & Toxicology, IU Center For AIDS Research, Indiana University School of Medicine, 635 Barnhill Drive, MS A-525, Indianapolis, IN 46202. Phone: (317) 274-1573. Fax: (317) 274-7714. E-mail: wjsulliv{at}iupui.edu.

{triangledown} Published ahead of print on 18 December 2006.

Antimicrobial Agents and Chemotherapy, March 2007, p. 1109-1111, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.01256-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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