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Antimicrobial Agents and Chemotherapy, April 2007, p. 1497-1499, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01239-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Fitness Cost of Staphylococcal Cassette Chromosome mec in Methicillin-Resistant Staphylococcus aureus by Way of Continuous Culture{triangledown}

Sui Mae Lee,1 Miriam Ender,2 Rajan Adhikari,1,2 John M. B. Smith,1 Brigitte Berger-Bächi,2 and Gregory M. Cook1*

Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, P.O. Box 56, Dunedin, New Zealand,1 Institute of Medical Microbiology, University of Zürich, Gloriastr. 32, CH8006 Zürich, Switzerland2

Received 3 October 2006/ Returned for modification 13 November 2006/ Accepted 17 December 2006

We examined the effect of introducing type I or IV staphylococcal cassette chromosome mec (SCCmec) elements on the growth yield of Staphylococcus aureus in glucose-limited continuous culture. Type I showed increased glucose consumption and ATP demand per gram of cells synthesized and decreased cell yield compared to those of the parent strain. In contrast, type IV SCCmec elements had no adverse energetic effect.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, P.O. Box 56, Dunedin, New Zealand. Phone: 64 3 479 7722. Fax: 64 3 479 8540. E-mail: greg.cook{at}stonebow.otago.ac.nz

{triangledown} Published ahead of print on 5 February 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1497-1499, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01239-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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