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Antimicrobial Agents and Chemotherapy, April 2007, p. 1512-1514, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00959-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro Studies with DQ-113 and Comparison Fluoroquinolones To Determine Propensities To Select Resistance in Gram-Positive Cocci{triangledown}

Seong Geun Hong, Ellen Smith Moland, Paul A. Wickman, Jennifer A. Black, Ashfaque Hossain, Nancy D. Hanson, and Kenneth S. Thomson*

Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, 2500 California Plaza, Omaha, Nebraska 68178

Received 2 August 2006/ Returned for modification 7 September 2006/ Accepted 27 December 2006

DQ-113 was compared in vitro to sitafloxacin, moxifloxacin, levofloxacin, and ciprofloxacin for potential to select mutational resistance in multiresistant staphylococci, pneumococci, and enterococci. Its ability to select less-susceptible mutants varied according to species, being lowest with staphylococci, intermediate with pneumococci, and greatest with enterococci.

* Corresponding author. Mailing address: Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, 2500 California Plaza, Omaha, NE 68178. Phone: (402) 280-4096. Fax: (402) 280-1875. E-mail: kstaac{at}creighton.edu

{triangledown} Published ahead of print on 12 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1512-1514, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00959-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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