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Antimicrobial Agents and Chemotherapy, April 2007, p. 1515-1519, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01201-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Effect of Antibiotics on Staphylococcus aureus Producing Panton-Valentine Leukocidin{triangledown}

Oana Dumitrescu, Sandrine Boisset, Cedric Badiou, Michele Bes, Yvonne Benito, Marie-Elisabeth Reverdy, François Vandenesch, Jerome Etienne, and Gerard Lina*

INSERM, U851, Lyon F-69008, France, and Université Lyon 1, Centre, National de référence des Staphylocoques, Faculté Laennec, Lyon F-69008, France

Received 25 September 2006/ Returned for modification 19 October 2006/ Accepted 10 January 2007

We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.

* Corresponding author. Mailing address: Centre National de Référence des Staphylocoques, INSERM E0230, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France. Phone: 33 472 11 07 75. Fax: 33 478 11 07 64. E-mail: gerard.lina{at}chu-lyon.fr

{triangledown} Published ahead of print on 22 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1515-1519, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01201-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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