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Antimicrobial Agents and Chemotherapy, April 2007, p. 1537-1540, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01468-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Metronidazole plus Rifampin Sterilizes Long-Term Dormant Mycobacterium tuberculosis{triangledown}

Elisabetta Iona, Federico Giannoni, Manuela Pardini, Lara Brunori, Graziella Orefici, and Lanfranco Fattorini*

Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy

Received 22 November 2006/ Returned for modification 10 December 2006/ Accepted 6 January 2007

Long-term nonreplicating (dormant) Mycobacterium tuberculosis populations (26-day-old cells) were sterilized by metronidazole plus rifampin, but not by metronidazole or rifampin alone, after 7 and 11 days of exposure to the drugs. Lower or no drug activity was observed against 19- or 12-day-old dormant or 5-day-old actively replicating populations.

* Corresponding author. Mailing address: Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39 06 49903167. Fax: 39 06 49387112. E-mail: lanfranco.fattorini{at}iss.it

{triangledown} Published ahead of print on 22 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1537-1540, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01468-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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