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Antimicrobial Agents and Chemotherapy, April 2007, p. 1549-1552, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01450-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Heterologous Production of Albicidin: a Promising Approach to Overproducing and Characterizing This Potent Inhibitor of DNA Gyrase{triangledown}

Eric Vivien,1 Delphine Pitorre,1 Stéphane Cociancich,1 Isabelle Pieretti,1 Dean W. Gabriel,2 Philippe C. Rott,1 and Monique Royer1*

Centre de Coopération Internationale en Recherche Agronomique pour le Développement, UMR Agro.M-Cirad-Inra BGPI, Campus International de Baillarguet, TA 41/K, 34398 Montpellier Cedex 5, France,1 Department of Plant Pathology, University of Florida, Gainesville, Florida 326112

Received 20 November 2006/ Returned for modification 18 December 2006/ Accepted 27 December 2006

The phytotoxin and polyketide antibiotic albicidin produced by Xanthomonas albilineans is a highly potent DNA gyrase inhibitor. Low yields of albicidin production have slowed studies of its chemical structure. Heterologous expression of albicidin biosynthetic genes in X. axonopodis pv. vesicatoria resulted in a sixfold increase in albicidin production, offering promising strategies for engineering overproduction.

* Corresponding author. Mailing address: Centre de Coopération Internationale en Recherche Agronomique pour le Développement, UMR Agro.M-Cirad-Inra BGPI, Campus International de Baillarguet, TA 41/K, 34398 Montpellier Cedex 5, France. Phone: (33) 4 99 62 48 44. Fax: (33) 4 99 62 48 08. E-mail: monique.royer{at}cirad.fr

{triangledown} Published ahead of print on 12 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1549-1552, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01450-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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