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Antimicrobial Agents and Chemotherapy, May 2007, p. 1835-1836, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01534-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Importance of Collection Tube during Clinical Studies of Oseltamivir{triangledown}

Niklas Lindegardh,1,2* Geraint R. Davies,1,3 Tran Tinh Hien,4 Jeremy Farrar,2,4 Pratap Singhasivanon,1 Nicholas P. J. Day,1,2 and Nicholas J. White1,2

Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand,1 Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom,2 Wellcome Trust Centre for Clinical Tropical Medicine, University of Liverpool, Liverpool, United Kingdom,3 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam4

Received 8 December 2006/ Returned for modification 11 January 2007/ Accepted 19 February 2007

Ex vivo conversion of the anti-influenza drug oseltamivir to its active metabolite can be inhibited by the esterase inhibitor dichlorvos or by using commercial fluoride-oxalate tubes. Oseltamivir and its active metabolite remain intact in plasma samples during a proposed virus heat inactivation step: incubation at 60°C for 45 min.

* Corresponding author. Mailing address: Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. Phone: 66 23541395. Fax: 66 23549169. E-mail: niklas{at}tropmedres.ac

{triangledown} Published ahead of print on 26 February 2007.

Antimicrobial Agents and Chemotherapy, May 2007, p. 1835-1836, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01534-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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Copyright © 2007 by the American Society for Microbiology. All rights reserved.