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Antimicrobial Agents and Chemotherapy, May 2007, p. 1879-1881, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.00914-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Immunomodulatory Effects of Fosfomycin in Experimental Human Endotoxemia{triangledown}

Robert Sauermann,1,{dagger} Claudia Marsik,2,{dagger} Ilka Steiner,1 Katja Seir,1 Tuende Cvitko,2 Markus Zeitlinger,1 Oswald Wagner,3 and Christian Joukhadar1,4*

Department of Clinical Pharmacology, Division of Pharmacokinetics,1 Department of Clinical Pharmacology, Division of Immunology and Hematology,2 Institute of Medical and Chemical Laboratory Diagnostics,3 Department of Internal Medicine IV, Division of Pulmology, Medical University of Vienna, Vienna, Austria4

Received 24 July 2006/ Returned for modification 1 November 2006/ Accepted 2 March 2007

To evaluate the effect of fosfomycin on proinflammatory cytokines, a bolus of 2 ng of bacterial lipopolysaccharide/kg of body weight was injected intravenously into healthy volunteers. After 2 h, subjects received 8 g of fosfomycin or placebo in a randomized crossover study design. The resulting concentrations of tumor necrosis factor alpha, interleukin-1β (IL-1β), and IL-6 expressed as protein and mRNA levels were almost identical with and without fosfomycin.

* Corresponding author. Mailing address: Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Phone: 43-1-40400-2981. Fax: 43-1-40400-2998. E-mail: christian.joukhadar{at}meduniwien.ac.at

{triangledown} Published ahead of print on 12 March 2007.

{dagger} These authors contributed equally to the study.

Antimicrobial Agents and Chemotherapy, May 2007, p. 1879-1881, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.00914-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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