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Antimicrobial Agents and Chemotherapy, June 2007, p. 2189-2191, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01442-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Staphylococcus aureus Strains That are Hypersusceptible to Resistance Gene Transfer from Enterococci{triangledown}

Julia M.-L. Sung and Jodi A. Lindsay*

Centre for Infection, Department of Cellular and Molecular Medicine, St. George's, University of London, London United Kingdom

Received 17 November 2006/ Returned for modification 26 December 2006/ Accepted 12 March 2007

We identified naturally occurring Staphylococcus aureus mutants of the restriction modification pathway SauI, including bovine lineage ST151. In a model of vancomycin resistance transfer from Enterococcus faecalis, ST151 isolates are 500 times more susceptible than human S. aureus isolates. The eradication of "hyperrecipient" strains may reduce the evolution of vancomycin-resistant S. aureus.

* Corresponding author. Mailing address: Department of Cellular and Molecular Medicine, St. George's, University of London, Cranmer Tce, London SW17 0RE, United Kingdom. Phone: 44 (0)208 725 0445. Fax: 44 (0)208 725 3487. E-mail: jlindsay{at}sgul.ac.uk

{triangledown} Published ahead of print on 19 March 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2189-2191, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01442-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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