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Antimicrobial Agents and Chemotherapy, June 2007, p. 2257-2259, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00095-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Paradoxical Effect of Echinocandins across Candida Species In Vitro: Evidence for Echinocandin-Specific and Candida Species-Related Differences{triangledown}

Georgios Chamilos,1 Russell E. Lewis,2 Nathaniel Albert,1 and Dimitrios P. Kontoyiannis1,2*

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas,1 College of Pharmacy, The University of Houston, Houston, Texas2

Received 22 January 2007/ Returned for modification 18 March 2007/ Accepted 3 April 2007

Paradoxical growth of some Candida isolates occurs at concentrations above the MIC for echinocandins. In 60 Candida bloodstream isolates from cancer patients (20 C. albicans isolates and 10 isolates each of C. parapsilosis, C. tropicalis, C. krusei, and C. glabrata), paradoxical growth was more frequent with caspofungin than micafungin or anidulafungin, was unrelated to MIC, and was strikingly absent in C. glabrata isolates.

* Corresponding author. Mailing address: Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030. Phone: (713) 792-6237. Fax: (713) 745-6839. E-mail: dkontoyi{at}mdanderson.org

{triangledown} Published ahead of print on 16 April 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2257-2259, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00095-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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