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Antimicrobial Agents and Chemotherapy, June 2007, p. 2260-2264, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00242-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

ß-Lactam Resistance in Haemophilus parasuis Is Mediated by Plasmid pB1000 Bearing blaROB-1{triangledown}

Alvaro San Millan, Jose Antonio Escudero, Ana Catalan, Silvia Nieto, Fidel Farelo, Magdalena Gibert, Miguel Angel Moreno, Lucas Dominguez, and Bruno Gonzalez-Zorn*

Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain

Received 16 February 2007/ Returned for modification 21 March 2007/ Accepted 5 April 2007

ß-Lactam resistance in Haemophilus parasuis is an emerging phenomenon that has not yet been characterized from a molecular perspective. Clinical high-level ß-lactam-resistant isolates from Spain bore a novel plasmid, pB1000, expressing a functionally active ROB-1 ß-lactamase. Pulsed-field gel electrophoresis was applied for the first time to H. parasuis and showed that ß-lactam resistance is due to clonal spread of a resistant strain, BB1018, bearing pB1000.

* Corresponding author. Mailing address: Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain. Phone: 34 91 3943707. Fax: 34 91 3943908. E-mail: bgzorn{at}vet.ucm.es

{triangledown} Published ahead of print on 16 April 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2260-2264, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00242-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • San Millan, A., Escudero, J. A., Gutierrez, B., Hidalgo, L., Garcia, N., Llagostera, M., Dominguez, L., Gonzalez-Zorn, B. (2009). Multiresistance in Pasteurella multocida Is Mediated by Coexistence of Small Plasmids. Antimicrob. Agents Chemother. 53: 3399-3404 [Abstract] [Full Text]  
  • Pina, S., Olvera, A., Barcelo, A., Bensaid, A. (2009). Trimeric Autotransporters of Haemophilus parasuis: Generation of an Extensive Passenger Domain Repertoire Specific for Pathogenic Strains. J. Bacteriol. 191: 576-587 [Abstract] [Full Text]  


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