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Antimicrobial Agents and Chemotherapy, July 2007, p. 2594-2596, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00580-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

RNAIII-Inhibiting-Peptide-Loaded Polymethylmethacrylate Prevents In Vivo Staphylococcus aureus Biofilm Formation{triangledown}

Paloma Anguita-Alonso ,1,{dagger},{ddagger} Andrea Giacometti,2,{dagger} Oscar Cirioni,2 Roberto Ghiselli,3 Fiorenza Orlando,4 Vittorio Saba,3 Giorgio Scalise,2 Milica Sevo,5 Marina Tuzova,7 Robin Patel,1,6 and Naomi Balaban5*

Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota,1 Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy,2 Department of General Surgery, I.N.R.C.A. I.R.R.C.S., Università Politecnica delle Marche, Ancona, Italy,3 Experimental Animal Models for Aging Units, Research Department, I.N.R.C.A. I.R.R.C.S., Ancona, Italy,4 Tufts University, Veterinary School, North Grafton, Massachusetts,5 Division of Clinical Microbiology, Mayo Clinic College of Medicine, Rochester, Minnesota,6 Boston University, Boston, Massachusetts7

Received 11 May 2006/ Returned for modification 31 August 2006/ Accepted 10 November 2006

Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.

* Corresponding author. Mailing address: Tufts University, Cummings School of Veterinary Medicine, Department of Biomedical Sciences, 200 Westboro Rd. Bldg. 20, North Grafton, MA 01536. Phone: (508) 887-4256. Fax: (508) 839-7911. E-mail: naomi.balaban{at}tufts.edu

{triangledown} Published ahead of print on 20 November 2006.

{dagger} Both authors contributed equally.

{ddagger} Present address: Department of Clinical Microbiology, Hospital Gregorio Marañon, Madrid, Spain.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2594-2596, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00580-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Simonetti, O., Cirioni, O., Ghiselli, R., Goteri, G., Scalise, A., Orlando, F., Silvestri, C., Riva, A., Saba, V., Madanahally, K. D., Offidani, A., Balaban, N., Scalise, G., Giacometti, A. (2008). RNAIII-Inhibiting Peptide Enhances Healing of Wounds Infected with Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 52: 2205-2211 [Abstract] [Full Text]  
  • Tsang, L. H., Daily, S. T., Weiss, E. C., Smeltzer, M. S. (2007). Mutation of traP in Staphylococcus aureus Has No Impact on Expression of agr or Biofilm Formation. Infect. Immun. 75: 4528-4533 [Abstract] [Full Text]  
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