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Antimicrobial Agents and Chemotherapy, July 2007, p. 2646-2648, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00231-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Lack of an Effect of Antibiotic Treatment on Prolonged Detection of Chlamydial DNA in Murine Genital Tract Infection{triangledown}

Dawn M. Reeves,1 Uma Nagarajan,1 Catherine O'Connell,1 Charles W. Andrews Jr.,2 and Toni Darville1*

Department of Pediatric Infectious Disease and Microbiology and Immunology, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, Arkansas,1 Rockdale Pathology Partners, Atlanta, Georgia2

Received 6 February 2007/ Returned for modification 14 March 2007/ Accepted 3 May 2007

Mice treated with antibiotics early or late after active infection had resolved were examined for chlamydial DNA in endocervical swabs. The early eradication of infection limited oviduct pathology, despite the continued detection of chlamydial DNA by nested PCR. Late antibiotic treatment had no effect on the ability to detect DNA or oviduct pathology.

* Corresponding author. Mailing address: Department of Pediatrics, Pediatric Infectious Diseases, Arkansas Children's Hospital, Little Rock, AR 72202. Phone: (501) 364-1416. Fax: (501) 354-3551. E-mail: darvilletonil{at}uams.edu

{triangledown} Published ahead of print on 14 May 2007.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2646-2648, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00231-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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