This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, Y.
Right arrow Articles by Clancy, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, Y.
Right arrow Articles by Clancy, C. J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2007, p. 2985-2987, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00308-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Measurement of Voriconazole Activity against Candida albicans, C. glabrata, and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography{triangledown}

Yanjun Li,1 M. Hong Nguyen,2,3,4 Hartmut Derendorf,1 Shaoji Cheng,2 and Cornelius J. Clancy2,4*

Department of Pharmaceutics, University of Florida College of Pharmacy,1 Departments of Medicine,2 Molecular Genetics and Microbiology, University of Florida College of Medicine,3 North Florida/South Georgia Veterans Health System, Gainesville, Florida4

Received 5 March 2007/ Returned for modification 25 April 2007/ Accepted 12 May 2007

We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achievable in human sera. HPLC confirmed that experiments were conducted at the desired steady-state voriconazole concentrations.

* Corresponding author. Mailing address: University of Florida College of Medicine, Box 100277, JHMHC, 1600 SW Archer Rd., Gainesville, FL 32610. Phone: (352) 392-4058. Fax: (352) 271-4566. E-mail: clancyn{at}medicine.ufl.edu

{triangledown} Published ahead of print on 21 May 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 2985-2987, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00308-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nguyen, K. T., Ta, P., Hoang, B. T., Cheng, S., Hao, B., Nguyen, M. H., Clancy, C. J. (2009). Anidulafungin Is Fungicidal and Exerts a Variety of Postantifungal Effects against Candida albicans, C. glabrata, C. parapsilosis, and C. krusei isolates. Antimicrob. Agents Chemother. 53: 3347-3352 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»