This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaiser, M.
Right arrow Articles by Vennerstrom, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaiser, M.
Right arrow Articles by Vennerstrom, J. L.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2007, p. 2991-2993, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00225-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160){triangledown}

Marcel Kaiser,1 Sergio Wittlin,1 Angela Nehrbass-Stuedli,1 Yuxiang Dong,2 Xiaofang Wang,2 Andrew Hemphill,4 Hugues Matile,3 Reto Brun,1 and Jonathan L. Vennerstrom2*

Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland,1 College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025,2 F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland,3 Institute of Parasitology, University of Bern, CH-3012 Bern, Switzerland4

Received 14 February 2007/ Returned for modification 30 April 2007/ Accepted 1 June 2007

Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.

* Corresponding author. Mailing address: College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025. Phone: (402) 559-5362. Fax: (402) 559-9543. E-mail: jvenners{at}unmc.edu

{triangledown} Published ahead of print on 11 June 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 2991-2993, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00225-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»