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Antimicrobial Agents and Chemotherapy, August 2007, p. 3008-3010, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00020-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Distribution of Radioactivity in Bone and Related Structures following Administration of [14C]Dalbavancin to New Zealand White Rabbits{triangledown}

Eric G. Solon,1 James A. Dowell,2 Jonghui Lee,2 S. Peter King,1 and Bharat D. Damle3*

Quest Pharmaceuticals Services, Newark, Delaware,1 Vicuron Pharmaceuticals, King of Prussia, Pennsylvania,2 Clinical Pharmacology, Pfizer Inc., New York, New York3

Received 8 January 2007/ Returned for modification 2 March 2007/ Accepted 27 May 2007

Penetration of dalbavancin into noninfected bone and joint tissues was assessed after an intravenous dose of 20 mg/kg (of body weight) [14C]dalbavancin given to rabbits. Drug-derived radioactivity, determined over 14 days by either liquid scintillation counting or autoradiography, remained above the MIC for common gram-positive pathogens that cause bone and joint infections.

* Corresponding author. Mailing address: Clinical Pharmacology, Pfizer Global Research & Development, 685 Third Avenue, Mail Stop 685/19/08, New York, NY 10017. Phone: (212) 733-4739. Fax: (646) 441-4493. E-mail: bharat.damle{at}pfizer.com

{triangledown} Published ahead of print on 4 June 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 3008-3010, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00020-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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