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Antimicrobial Agents and Chemotherapy, August 2007, p. 3033-3035, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00264-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers){triangledown}

Yuxiang Dong,1 Darren Creek,2 Jacques Chollet,3 Hugues Matile,4 Susan A. Charman,2 Sergio Wittlin,3 James K. Wood,5 and Jonathan L. Vennerstrom1*

College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, Nebraska 68198-6025,1 Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia,2 Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland,3 F. Hoffmann-La Roche, Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland,4 Department of Chemistry, University of Nebraska at Omaha, 60th and Dodge Street, Omaha, Nebraska 68192-01095

Received 21 February 2007/ Accepted 30 April 2007

Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron(II)-mediated activation.

* Corresponding author. Mailing address: College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025. Phone: (402) 559-5362. Fax: (402) 559-9543. E-mail: jvenners{at}unmc.edu

{triangledown} Published ahead of print on 7 May 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 3033-3035, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00264-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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