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Antimicrobial Agents and Chemotherapy, September 2007, p. 3404-3406, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.01563-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Increasing Ceftriaxone Resistance and Multiple Alterations of Penicillin-Binding Proteins among Penicillin-Resistant Streptococcus pneumoniae Isolates in Taiwan{triangledown}

Cheng-Hsun Chiu,1,2,{dagger}* Lin-Hui Su,2,3,{dagger} Yhu-Chering Huang,1,2 Jui-Chia Lai,1 Hsiu-Ling Chen,1 Tsu-Lan Wu,2,3 and Tzou-Yien Lin1,2

Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital,1 Chang Gung University College of Medicine,2 Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan3

Received 18 December 2006/ Returned for modification 7 February 2007/ Accepted 15 June 2007

The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.

* Corresponding author. Mailing address: Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan. Phone: 886 3 3281200. Fax: 886 3 3288957. E-mail: chchiu{at}adm.cgmh.org.tw

{triangledown} Published ahead of print on 25 June 2007.

{dagger} C.-H. Chiu and L.-H. Su contributed equally to this work.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3404-3406, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.01563-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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